My 2nd Lupron injection - November 24, 2025

I have to admit that being back at the Zimmer Cancer Center here in Wilmington is a little surreal, and I also feel like I have come back home. I am thankful for the opportunity to receive care locally in coordination with Duke.

Yesterday I received my 2nd Lupron injection - 21 days after my 1st. Again, it was administered in my flank, this time switching the left side. Very little discomfort, just a pinch. No noticeable side effects so far. In fact, I ran 2 miles, then walked 3 this morning and felt great.

I appreciated the opportunity to see Dr. Robinson yesterday. He is so incredibly kind and caring. I felt seen and heard.

He allowed me to have blood tests yesterday that I requested, and, at my request, he has ordered those same blood tests for December 8 - two days before my surgery with Dr. Rossi and Dr. Zani.

Further, we scheduled my 3rd Lupron injection and next office visit with him for December, as well as a follow-up visit in January before the WDW Half Marathon (which I am still hoping to complete).

Tomorrow I’ll be two weeks out from my scheduled liver resection and debulking surgery at Duke.

This week’s question - Lupron

Many friends have asked, “So, how’s it going with Lupron?” I want to keep track of any side effects here, just like I did when I started taking Letrozole in June of 2023.

For the first seven days after taking Lupron (and continuing to take Letrozole), I did find myself feeling emotional (read: weepy) quite a bit and at times feeling a sense of dread (read: anxiety). Neither of which is normal for me, but I have had a lot going on. So, it could be the buildup of stress - or it could be the Lupron/Letrozole combo - or it could be both. The other potential side effect has been fatigue, but again. I’ve had a lot going on, and we had the return to Eastern Standard Time this weekend. That could explain the fatigue, as well.

Regardless, it has been tolerable.

My First Lupron Injection

I received my first injection of Lupron today, October 28. It was a painless injection in my hip. I really didn't feel a thing.

I'm hopeful the days ahead will be equally uneventful, but just like I did with Letrozole, I will post regular updates on how I am feeling on Lupron and (eventually) whether or not it is efficacious for me.

October 28 update

After nearly a month of feeling like things were moving so slowly, I'm happy to share that the last two days have been busy with progress.

Yesterday afternoon I got the call that Lupron had been approved by insurance and that I could come in today for my first infection. 🙌

Today I got notification that the December 4 surgery is a go, with Dr. Rossi and Dr. Zani both being available to do their parts of the procedure.

I got my first Lupron injection, scheduled my second for November 24, and also had my pre-anesthesia consultation this afternoon. I'm feeling really good about the plan and am eager to move forward.

This is what was on the wall in the procedure room today.